Unlocking Brain Health: How Erinacines and Hericenones from Lion's Mane Cross the Blood-Brain Barrier

As the founder of South Middle Mushrooms, I've spent countless hours not just growing Lion's Mane (Hericium erinaceus), but also studying its extraordinary properties. What started as a passion for mushroom cultivation quickly evolved into an obsession with brain health—especially when I began experiencing improved focus, clarity, and mental stamina from using my own tinctures.

So what makes Lion’s Mane such a powerful brain tonic? It comes down to two unique compounds: erinacines and hericenones. These aren’t just buzzwords; they are key players in the mushroom’s nootropic and neuroregenerative effects.

Erinacines & Hericenones: The Dynamic Duo for Brain Health

Lion’s Mane is unlike any other mushroom because it contains bioactive molecules that stimulate Nerve Growth Factor (NGF)—a protein essential for the development, maintenance, and survival of neurons. Hericenones are found primarily in the fruiting body, while erinacines are present in the mycelium. Together, they cover both ends of the spectrum.

In studies, these compounds have shown the ability to:

• Promote neurogenesis (growth of new brain cells)

• Support myelin sheath repair, which protects nerve fibers

• Potentially reduce symptoms of neurodegenerative conditions like Alzheimer’s and Parkinson’s

And this isn’t just theoretical. Anecdotally, my own memory, word recall, and stress resilience have noticeably improved since incorporating Lion’s Mane into my routine.

Crossing the Blood-Brain Barrier (BBB)

Here’s where the real science magic happens. The blood-brain barrier (BBB) is a protective shield that prevents harmful substances in the bloodstream from entering the brain. Only certain compounds—typically those that are small and lipophilic (fat-soluble)—can pass through.

Both erinacines and hericenones have shown lipophilic properties, which enable them to cross the BBB. This is vital because it allows these compounds to:

• Directly stimulate NGF inside the brain

• Help the brain repair damaged neurons

• Influence cognitive performance in a meaningful, measurable way

One in-vitro study even demonstrated that erinacine A, in particular, elevated NGF synthesis in astrocytes (a type of glial cell in the brain) significantly more than other natural compounds.

Why I Use Dual Extraction

In my own tincture production, I prioritize dual-extraction—pulling out both water-soluble and alcohol-soluble compounds. Water extraction captures the polysaccharides (great for immune support), while alcohol extraction targets those precious hericenones and erinacines.

I want my customers to get the full spectrum of what Lion’s Mane has to offer—not just a memory boost, but long-term neural support that can truly shift mental well-being over time. That’s why I formulate my tinctures using both mycelium and fruiting body extracts, sustainably grown and processed in-house.

The Takeaway

Lion’s Mane is one of nature’s most promising tools for cognitive enhancement and neurological repair. The fact that erinacines and hericenones can pass through the blood-brain barrier makes this mushroom stand out in the world of functional supplements.

If you’re new to Lion’s Mane or looking for a clean, potent product, try a dual-extract tincture made with care—like the ones I handcraft at South Middle Mushrooms. Your brain might just thank you.